Sit on the Left side of the plane for the best views on flights from Buffalo to Chicago. While takeoff offers excellent views of Lake Ontario and the Niagara region, the landing approach provides more dramatic urban scenery with the Chicago skyline and Lake Michigan. Left-side seats capture the most visually distinctive moment of the flight.

During takeoff from Buffalo Niagara International (BUF), sit on the Right side for the best views. Right-side seats offer views of Lake Ontario and the Niagara River gorge during the initial climb-out. The aircraft typically departs westbound, and right-side windows face north toward the lake and the dramatic escarpment carved by Niagara Falls. Notable sights include: Lake Ontario (northern shore), Niagara River gorge, Niagara Escarpment, Lewiston-Queenston area.

When landing at Chicago Midway International (MDW), sit on the Left side for the best views. Left-side seats provide views of the Chicago skyline and Lake Michigan during the descent approach. Aircraft typically descend from the northeast on approach to Midway, making left-side windows ideal for seeing downtown Chicago's high-rises and the lakefront. Notable sights include: Lake Michigan shoreline, Chicago downtown skyline, Des Plaines River, Midway Airport area.

The flight from Buffalo Niagara International (BUF) to Chicago Midway International (MDW) takes Approximately 2 hours 15 minutes.

The flight path crosses Lake Erie's eastern basin, then passes over northern Ohio and Indiana. Notable midpoint features include the southern shore of Lake Erie (visible from altitude as a distinct water-land boundary), the industrial corridor around Cleveland-Akron area, and the flat agricultural plains of northwestern Ohio and northeastern Indiana. The Maumee River valley and various smaller lakes dot the landscape between Buffalo and Chicago.