Sit on the Right side of the plane for the best views on flights from Buenos Aires to Frankfurt. The right side captures the spectacular Rio de la Plata and Buenos Aires on departure, and during the long transatlantic crossing offers views of the Atlantic coast of West Africa (Senegal, Mauritania coastline) as the route curves northeast. On descent into Frankfurt the right side sees the Odenwald forested hills and Rhine valley. The departure view alone — the world's widest river estuary — makes right the stronger overall choice.

During takeoff from Ezeiza Ministro Pistarini (EZE), sit on the Right side for the best views. EZE typically departs on runway 11 (eastward) or 29 (westward). On the dominant runway 11 departure heading east, the right side faces north toward the Rio de la Plata estuary and the sprawling Buenos Aires metropolitan grid. The estuary is enormous and unmistakable from altitude, and the city's street pattern is clearly visible during climb-out. Notable sights include: Rio de la Plata estuary (vast brown-water river mouth), Buenos Aires city grid and downtown skyline, Dock Sud industrial port area, Quilmes and southern suburban sprawl.

When landing at Frankfurt Main (FRA), sit on the Left side for the best views. Frankfurt typically lands on runway 25L/25R (westward approach) or 07L/07R (eastward). On the common westward approach over the city, the left side faces south toward the Frankfurt city center, the Main River bend, and the Taunus hills beyond. The Rhine-Main confluence and the distinctive Frankfurt skyline are clearly visible from the left during final approach. Notable sights include: Frankfurt am Main skyline (Bankenviertel towers), Main River bend through the city, Taunus hills to the north-northwest, Rhine-Main floodplain agricultural land.

The flight from Ezeiza Ministro Pistarini (EZE) to Frankfurt Main (FRA) takes Approximately 13 to 14 hours.

The route tracks northeast across the South Atlantic, passing well east of Recife, Brazil, then crossing the equatorial Atlantic toward the Cape Verde islands region. The flight crosses the West African coast near Dakar, Senegal, then traverses the Sahara Desert over Mali and Algeria — a vast, featureless sand and rock landscape visible in daylight. The route then crosses the Mediterranean near Tunisia or Sicily, enters Europe over northern Italy or Switzerland, and descends across southern Germany through the Rhine-Main corridor into Frankfurt.