Sit on the Right side of the plane for the best views on flights from Buenos Aires to Panama City. While takeoff favors left seats for Buenos Aires departure views, the landing approach over the Panama Canal and Gatun Lake is the more distinctive and geographically significant segment of this route. Right seats capture the canal's engineering marvel and the dramatic transition from rainforest to urban Panama City.

During takeoff from Ezeiza Ministro Pistarini (EZE), sit on the Left side for the best views. EZE typically departs runway 09 (westbound) or 27 (eastbound). Left seats facing west show the Río de la Plata estuary and the sprawling Buenos Aires metropolitan area receding behind. Eastbound departures from runway 27 favor right seats, but westbound is more common for northbound routes to Panama. Notable sights include: Río de la Plata (broad muddy estuary immediately below), Buenos Aires city grid and port facilities, Aeroparque Jorge Newbery (smaller airport visible northeast across the river), Tigre Delta wetlands to the north.

When landing at Tocumen International (PTY), sit on the Right side for the best views. PTY (Tocumen) has two parallel runways; approaches typically come from the northeast over the Caribbean. Right seats provide clear views of the Panama Canal approach, the Gatun Lake system, and the urban sprawl of Panama City. The descent path naturally aligns the canal and surrounding geography on the right side of the aircraft. Notable sights include: Panama Canal (Gatun Locks and cut visible), Gatun Lake (large freshwater reservoir), Panama City skyline and Casco Viejo (old town), Colón and Caribbean coastline to the north.

The flight from Ezeiza Ministro Pistarini (EZE) to Tocumen International (PTY) takes Approximately 5 hours 15 minutes.

The flight path crosses the Caribbean coast of Colombia and Venezuela at cruise altitude (typically 35,000 feet). At that altitude, the Andes' northern extension (Sierra de Perijá) appears as a distant ridge on the left (east) during the northbound climb. The Caribbean Sea dominates the center of the route. The Maracaibo Basin and Lake Maracaibo (if visible through haze) appear as a large inland water body on the left. As the aircraft approaches Panama, the Darién Gap rainforest (extremely remote, roadless jungle) fills the landscape below before the Canal Zone becomes visible.