Sit on the Left side of the plane for the best views on flights from Frankfurt to St. Louis. Left side wins at both ends of the flight. Over the Atlantic the views are similar on both sides, but the left side captures the best of the departure scenery over Frankfurt and the Rhine-Main region, and delivers the definitive arrival view of the Mississippi River and Gateway Arch on approach to STL.

During takeoff from Frankfurt Main (FRA), sit on the Left side for the best views. Frankfurt's main departure runways (07L/07R heading east, or 25L/25R heading west) mean westbound transatlantic flights typically depart heading west or northwest. A left-side seat gives you views over Frankfurt city center, the Main River, and the Taunus hills as the aircraft climbs and turns northwest. The right side faces south toward less distinctive terrain. Notable sights include: Frankfurt city skyline and Main River bend, Taunus hills and ridgeline to the northwest, Rhine River valley visible to the west, Wiesbaden and Mainz confluence area.

When landing at Lambert St Louis International (STL), sit on the Left side for the best views. Lambert STL typically uses runways 11/29 or 12L/30R. Westbound arrivals from the east usually approach from the east or northeast, meaning the aircraft descends over Illinois before crossing the Mississippi. A left-side seat gives a direct view of the Mississippi River, the Gateway Arch, and downtown St. Louis as you cross into Missouri on final approach. Notable sights include: Mississippi River and its wide floodplain, Gateway Arch and downtown St. Louis skyline, Missouri River confluence north of the city, East St. Louis Illinois urban grid.

The flight from Frankfurt Main (FRA) to Lambert St Louis International (STL) takes Approximately 9 to 10 hours.

The flight tracks northwest over the Netherlands and UK, then across the North Atlantic via the North Atlantic Tracks, passing south of Greenland and Iceland. Over Canada the route crosses Newfoundland and Quebec, then descends across the Great Lakes region or Ohio Valley. Mid-flight features include the Irish coastline, the vast North Atlantic with occasional iceberg fields near Greenland, the Newfoundland coastline, and the St. Lawrence River valley on descent.