Sit on the Left side of the plane for the best views on flights from St. Louis to Frankfurt. While takeoff favors the right side for the Mississippi River view, the Frankfurt approach on the left side offers more varied and recognizable scenery, including the city skyline and Taunus hills, giving it a slight edge over a flight that's otherwise dominated by flat Midwest and Atlantic terrain.

During takeoff from Lambert St Louis International (STL), sit on the Right side for the best views. Departing STL to the east/northeast, the right side offers views of the Mississippi River and the Illinois floodplain confluence area as the flight climbs out over the Midwest. It's mostly flat farmland after that, but the river crossing near St. Louis is a nice early feature. Notable sights include: Mississippi River, St. Louis riverfront and Gateway Arch area, Illinois floodplain farmland.

When landing at Frankfurt Main (FRA), sit on the Left side for the best views. Arriving into Frankfurt from the west, the left side typically catches views of the Rhine-Main river plain, the wooded hills of the Taunus range, and the dense patchwork of towns and vineyards before descending into the airport. The approach often reveals the Frankfurt skyline's distinctive skyscraper cluster. Notable sights include: Rhine-Main river plain, Taunus hills, Frankfurt skyline skyscrapers, Main River.

The flight from Lambert St Louis International (STL) to Frankfurt Main (FRA) takes 8h 40m.

The route crosses the Appalachian Mountains near the East Coast, then several hours of open North Atlantic Ocean, with landfall over Ireland or the UK before crossing the English Channel or North Sea into continental Europe.