Sit on the Right side of the plane for the best views on flights from Sao Paulo to Cuiaba. Right-side seats capture the dramatic Serra da Cantareira during departure and offer better views of the transition from Atlantic Plateau to central Brazilian plateau during cruise. The takeoff scenery is more visually striking than the landing approach.

During takeoff from Guarulhos (GRU), sit on the Right side for the best views. Departing GRU heading northwest, right-side seats face the Serra da Cantareira mountain range and the sprawling urban landscape of greater São Paulo. Left seats look toward the industrial suburbs and flat terrain with less visual interest. Notable sights include: Serra da Cantareira (northern escarpment), Guarulhos urban sprawl, Tietê River valley, Atlantic Plateau edge.

When landing at Marechal Rondon (CGB), sit on the Left side for the best views. Approaching CGB from the southeast, left-side seats offer views of the Cuiabá River valley and the city's position on the cerrado plateau. Right seats face less distinctive terrain as the approach vector aligns with the city's eastern approach corridor. Notable sights include: Cuiabá River (meandering through valley), Cerrado plateau grasslands, Marechal Rondon Airport, city of Cuiabá urban center.

The flight from Guarulhos (GRU) to Marechal Rondon (CGB) takes Approximately 2 hours 15 minutes.

The flight path crosses the interior plateau of São Paulo state, passing over the Paraná River valley (visible as a major river system and escarpment edge around 1 hour into flight), transitioning from Atlantic Plateau terrain to the flatter cerrado grasslands of Mato Grosso. The landscape gradually shifts from forested escarpment regions to open savanna with scattered vegetation. No major mountain ranges cross the direct route, but the Paraná River gorge and its associated plateau edge provide the most notable midpoint geographical feature.