Sit on the Left side of the plane for the best views on flights from Sao Paulo to Guayaquil. While takeoff favors the right for metropolitan views, the landing approach over the Guayas estuary and mangrove system is the more distinctive and geographically significant feature of this route. Left seats capture this unique tropical wetland geography that defines Guayaquil's setting.

During takeoff from Guarulhos (GRU), sit on the Right side for the best views. GRU typically departs eastbound (runways 09L/09R). Right-side seats face north initially, offering views of the Serra da Cantareira mountain range and the sprawling São Paulo metropolitan area before turning northwest toward Ecuador. Notable sights include: Serra da Cantareira (northern escarpment), Tietê River valley, São Paulo urban sprawl extending to the horizon, Guarulhos industrial zone.

When landing at Simon Bolivar International (GYE), sit on the Left side for the best views. GYE approaches from the east (runways 09/27, typically 09 for westbound arrivals). Left-side seats face south during descent, revealing the Guayas River estuary, mangrove wetlands, and the Pacific coastal plain—the defining geography of Guayaquil's location. Notable sights include: Guayas River estuary with mangrove channels, Pacific coastal plain, Cerro Santa Ana (urban hill), Guayaquil city waterfront.

The flight from Guarulhos (GRU) to Simon Bolivar International (GYE) takes Approximately 2 hours 45 minutes.

The flight path crosses the Colombian border region and the western Andes foothills. Notable features include the Cauca River valley (visible around 1 hour into flight), the Nariño Plateau near the Ecuador-Colombia border, and the descent into Ecuador's coastal plain. The Andes' western escarpment becomes visible as the aircraft descends toward Guayaquil, with the Pacific coastal lowlands spreading below.