Sit on the Right side of the plane for the best views on flights from Sao Paulo to Santa Cruz. Right-side seats capture the most dramatic geography: the Serra da Cantareira and São Paulo basin during departure, then the transition across the Brazilian plateau, and finally the Río Grande and cerrado landscape during approach. Left seats miss the northern mountains at takeoff.

During takeoff from Guarulhos (GRU), sit on the Right side for the best views. GRU typically departs on runway 27L or 27R (westbound). Right-side seats face north during initial climb, offering views of the Serra da Cantareira and the sprawling São Paulo metropolitan area before turning southwest toward Bolivia. Notable sights include: Serra da Cantareira (northern mountain range), Tietê River valley, São Paulo urban sprawl extending north and east, Guarulhos city grid.

When landing at Viru Viru International (VVI), sit on the Left side for the best views. VVI uses runway 02/20; approaches typically come from the east. Left-side seats during descent face south and southwest, revealing the Río Grande (Paraguay River) and the transition from cerrado grasslands into Santa Cruz's agricultural zones and urban development. Notable sights include: Río Grande (Paraguay River) defining Bolivia-Paraguay border, cerrado savanna landscape with scattered vegetation, Santa Cruz city sprawl, agricultural grid patterns of soy and cattle ranches.

The flight from Guarulhos (GRU) to Viru Viru International (VVI) takes Approximately 2 hours 45 minutes to 3 hours 15 minutes.

The flight path crosses the Brazilian plateau (Planalto Paulista) heading west-southwest. Notable features include the Paraná River valley (visible around 1 hour into flight, marking the São Paulo-Paraná border), scattered cerrado vegetation and agricultural zones in Mato Grosso do Sul, and the gradual transition from subtropical forest remnants to open grassland savanna as the aircraft approaches Bolivia. The terrain becomes progressively flatter and more open westward. No major mountain ranges block this route—the Serra da Mantiqueira and Serra Geral remain to the south and east of the flight path.