Sit on the Left side of the plane for the best views on flights from Las Vegas to St. Louis. The left side wins overall because the spectacular landing approach over the Mississippi River and Gateway Arch is one of the most iconic urban aerial views in the American Midwest. The takeoff view from the right is excellent but the landing experience on the left is more consistently rewarding and geographically distinctive.

During takeoff from Mc Carran International (LAS), sit on the Right side for the best views. McCarran's primary departure runway 26L/26R sends aircraft westward before turning northeast toward St. Louis. A right-side seat captures the Las Vegas Strip and downtown Las Vegas as the aircraft banks left over the valley, with the Spring Mountains and Red Rock Canyon escarpment clearly visible to the southwest. Left-side passengers face the Sunrise Mountain and Frenchman Mountain ridgelines, which are less dramatic. Notable sights include: Las Vegas Strip hotels and casinos, Red Rock Canyon escarpment and Wilson Cliffs, Lake Mead reservoir to the east, Hoover Dam visible in the distance.

When landing at Lambert St Louis International (STL), sit on the Left side for the best views. Lambert STL primarily uses runways 12L/12R or 30L/30R depending on wind. On the common approach from the west on runway 30, aircraft track eastward and the Mississippi River, the Gateway Arch, and downtown St. Louis are clearly visible on the left side. The Arch sits directly on the riverbank and is unmistakable from the air at low altitude. Notable sights include: Gateway Arch and downtown St. Louis skyline, Mississippi River, Missouri River confluence north of the city, East St. Louis Illinois riverfront.

The flight from Mc Carran International (LAS) to Lambert St Louis International (STL) takes Approximately 2 hours 45 minutes to 3 hours.

The flight crosses the Colorado River near Hoover Dam shortly after departure, then tracks northeast over the Arizona Strip and southern Utah's canyon country including portions of the Colorado Plateau. The route crosses the Four Corners region and then transitions over the southern Rockies foothills before crossing into the Great Plains of Kansas and Missouri. The Ozark Plateau becomes visible in the final 30 minutes as rolling forested hills before the descent into St. Louis.