Sit on the Left side of the plane for the best views on flights from St. Louis to Las Vegas. The left side captures the dramatic St. Louis departure with the Gateway Arch and Mississippi River, and through the cruise phase offers views of the Oklahoma and Texas panhandle terrain, the New Mexico high desert, and the Colorado Plateau edge. The right side wins at landing but the left side provides more sustained interest across the full flight.

During takeoff from Lambert St Louis International (STL), sit on the Left side for the best views. Lambert typically departs westbound on runway 12L/30R or 11/29, meaning a westbound departure puts the Mississippi River and downtown St. Louis on the left side during the initial climb and turn. The Gateway Arch and the St. Louis skyline are clearly visible from the left window as the aircraft banks southwest. Notable sights include: Gateway Arch and downtown St. Louis, Mississippi River, Forest Park, Busch Stadium.

When landing at Mc Carran International (LAS), sit on the Right side for the best views. Las Vegas McCarran typically receives westbound arrivals from the east on runway 26L/26R, meaning the aircraft approaches from the east with the Las Vegas Strip visible on the right side. The Spring Mountains and Red Rock Canyon escarpment are also on the right during the descent. Notable sights include: Las Vegas Strip, Red Rock Canyon escarpment, Spring Mountains (Charleston Peak), Lake Mead on the distant horizon to the northeast.

The flight from Lambert St Louis International (STL) to Mc Carran International (LAS) takes Approximately 3 hours 15 minutes.

The flight tracks southwest across Missouri, then over the Ozark Plateau into Oklahoma and the Texas Panhandle, crossing the Canadian River breaks and the high plains. Over New Mexico the route passes north of Tucumcari and crosses the Sangre de Cristo foothills before entering the Colorado Plateau and Painted Desert region of northeastern Arizona. The Grand Canyon is typically 80-120 miles north of the flight path and not directly visible, but the general canyon country terrain of northern Arizona is visible below. The route then crosses the Mojave Desert into Nevada.