Sit on the Right side of the plane for the best views on flights from Orlando to St. Louis. Right-side seats capture the most dramatic features: eastbound departure views of Florida's lake systems, and during the cruise phase westward, the right side faces the general direction of travel. However, left seats gain advantage on final approach into STL for the Mississippi River and Gateway Arch. Right edges out left for the full journey.

During takeoff from Orlando International (MCO), sit on the Right side for the best views. MCO typically departs eastbound (Runways 09L/09R) or westbound (Runways 27L/27R). Right-side seats on eastbound departures offer views of the Atlantic coast and inland lakes; westbound departures favor right seats for views of central Florida's lake systems and the beginning of the climb westward. Notable sights include: Lake Apopka (large freshwater lake directly west of MCO), the Florida Turnpike corridor, downtown Orlando skyline to the northwest, and the chain of smaller lakes dotting central Florida.

When landing at Lambert St Louis International (STL), sit on the Left side for the best views. STL uses Runways 30L/30R (eastbound) or 12L/12R (westbound). Approaching from the east (typical for flights from Florida), left-side seats provide views of the Mississippi River, the Gateway Arch, and downtown St. Louis before touchdown. Notable sights include: The Mississippi River (distinctive serpentine curve), the Gateway Arch (iconic 630-foot monument in downtown St. Louis), the confluence region where the Missouri River meets the Mississippi, and the Illinois bluffs across the river.

The flight from Orlando International (MCO) to Lambert St Louis International (STL) takes Approximately 2 hours 45 minutes to 3 hours.

The flight path crosses central Georgia (Chattahoochee River valley visible in early cruise), then transitions into Tennessee with the Cumberland Plateau terrain becoming visible. The Tennessee River's serpentine curves are notable around Knoxville area. As the flight continues northwest, the Appalachian foothills fade into the flatter terrain of Kentucky and southern Illinois. The Ohio River may be visible during descent into the St. Louis region, appearing as a wide, meandering waterway in the landscape.