Sit on the Right side of the plane for the best views on flights from Mexicali to Sao Paulo. While takeoff offers interesting delta and agricultural views, the landing approach on the right side showcases the dramatic Serra da Mantiqueira escarpment—one of South America's most visually distinctive geographical features. The contrast between the coastal plain and the mountain wall is far more dramatic than the takeoff scenery.

During takeoff from General Rodolfo Sanchez Taboada International (MXL), sit on the Left side for the best views. Left side offers views of the Colorado River delta and the Imperial Valley's agricultural grid as the aircraft climbs northeast. The river's distinctive braided channels and the sharp boundary between irrigated farmland and desert are clearly visible during initial climb. Notable sights include: Colorado River delta, Imperial Valley agricultural fields, Salton Sea (distant, southeast), Sierra de Juárez mountains (southeast horizon).

When landing at Guarulhos (GRU), sit on the Right side for the best views. Right side provides excellent views of the Atlantic coastal approach and the Serra da Mantiqueira mountains as the aircraft descends toward São Paulo. The dramatic escarpment and the transition from coastal lowlands to the interior plateau are striking visual features. Notable sights include: Serra da Mantiqueira escarpment, Paraíba River valley, Atlantic coastal plain, São Paulo metropolitan sprawl.

The flight from General Rodolfo Sanchez Taboada International (MXL) to Guarulhos (GRU) takes 9h 15m.

The flight path crosses central Mexico (Sierra Madre Occidental visible from altitude), then proceeds over the Yucatan Peninsula and Caribbean, with the Yucatan Channel and Gulf of Mexico visible during the southern portion of the route. The aircraft then crosses into South America over the Caribbean coast of Colombia/Venezuela, follows the interior over the Amazon basin (vast forested terrain with river systems), and approaches São Paulo from the northeast, descending over the interior plateau before reaching the coastal escarpment.