Sit on the Right side of the plane for the best views on flights from Santiago to Frankfurt. The right side delivers the most spectacular single moment of the flight — the Andes wall on departure from Santiago is genuinely world-class. During the long transoceanic and transatlantic cruise, neither side has a decisive advantage, but the Andes view alone makes right the overall winner for this route.

During takeoff from Arturo Merino Benitez International (SCL), sit on the Right side for the best views. SCL's primary departure runway 17/35 means northbound departures on 35 climb out heading north, then the aircraft typically turns east. The right side faces east toward the Andes, giving a dramatic view of the Cordillera including Aconcagua and the snow-capped peaks directly east of Santiago. The left side looks west over the flat Central Valley and coastal range, which is far less dramatic. Notable sights include: Aconcagua (6,961m, visible to the northeast), Tupungato volcano, the urban sprawl of Greater Santiago in the valley below, the snow line of the Cordillera Principal.

When landing at Frankfurt Main (FRA), sit on the Left side for the best views. Frankfurt's primary landing approach on runway 25L/25R comes in from the east heading west, so the left side faces south toward the Rhine River, the Taunus hills, and Frankfurt's city skyline. The right side looks north over less distinctive suburban terrain. Runway 07 approaches from the west are less common for long-haul arrivals. Notable sights include: Frankfurt city skyline (Bankenviertel skyscrapers), Rhine-Main confluence near Mainz, Taunus hills to the north, Main River winding through the city.

The flight from Arturo Merino Benitez International (SCL) to Frankfurt Main (FRA) takes Approximately 14 to 15 hours.

The route typically tracks northeast from Santiago, crossing the Andes into Argentina, then over the South Atlantic toward West Africa. The flight passes over or near the Brazilian interior (Amazon basin visible as unbroken green canopy), crosses the equatorial Atlantic, passes near the Cape Verde islands, then crosses over the Iberian Peninsula — the Pyrenees and Spanish meseta may be visible — before descending into central Europe over France and the Rhine valley.