Sit on the Right side of the plane for the best views on flights from Buffalo to Las Vegas. The right side wins overall. While the left side has the better Buffalo departure view, the right side delivers the more dramatic scenery across the flight: the southern shore of Lake Erie early on, then the Ohio and Indiana flatlands, the Mississippi River crossing, the Ozarks, the Texas panhandle plains, New Mexico high desert, Arizona canyon country, and the spectacular Las Vegas arrival with the Spring Mountains. The right side consistently faces south and southwest, tracking the more interesting terrain on this route.

During takeoff from Buffalo Niagara International (BUF), sit on the Left side for the best views. BUF typically departs runway 23 heading southwest, then turns west. The left side gets a clear view of Lake Erie stretching to the southwest and the Niagara River corridor. You can also catch downtown Buffalo's waterfront and the Peace Bridge crossing into Canada. Notable sights include: Lake Erie shoreline, Niagara River, downtown Buffalo waterfront, Peace Bridge.

When landing at Mc Carran International (LAS), sit on the Right side for the best views. Las Vegas typically lands on runways 26L/26R approaching from the east, meaning the aircraft comes in from the desert east of the city. The right side gives you the Las Vegas Strip laid out clearly below, with the Spring Mountains and Red Rock Canyon visible to the west beyond the city. Notable sights include: Las Vegas Strip, Spring Mountains (Charleston Peak), Red Rock Canyon escarpment, Lake Mead to the east.

The flight from Buffalo Niagara International (BUF) to Mc Carran International (LAS) takes Approximately 4 hours 15 minutes to 4 hours 45 minutes.

The route crosses Lake Erie's southern shore, then the flat agricultural plains of Ohio and Indiana. Over Missouri the Mississippi and Missouri Rivers are visible. The flight then crosses the Ozark Plateau, the Oklahoma and Texas panhandle grasslands, the Llano Estacado, and enters New Mexico over the high desert plateau country. The Sandia Mountains near Albuquerque may be visible to the south. Arizona brings the Colorado Plateau, with canyon systems and mesas visible below. The route descends toward Nevada crossing the Mojave Desert before the Las Vegas Valley comes into view.