Sit on the Left side of the plane for the best views on flights from Charlotte to Key West. While the right side wins at takeoff for the Charlotte skyline, the left side dominates the majority of the flight. Cruising southbound over South Carolina and Georgia, the left side tracks closer to the Atlantic coastal plain and eventually picks up the Florida peninsula's western edge and the Gulf coastline. On descent into Key West, the left side delivers the definitive view of the island and the extraordinary shallow-water color of the surrounding flats, which is the visual highlight of the entire route.

During takeoff from Charlotte Douglas International (CLT), sit on the Right side for the best views. CLT's primary departure runways (18C/36C and 18L/36L) oriented north-south mean southbound departures swing southeast over the Charlotte metro. The right side picks up the downtown Charlotte skyline and the Catawba River as the aircraft climbs out heading south. Notable sights include: Downtown Charlotte skyline, Catawba River/Lake Wylie, South Carolina Piedmont farmland, Lake Norman (briefly visible to the north on climb).

When landing at Key West International (EYW), sit on the Left side for the best views. Key West International sits on the eastern end of the island, and aircraft typically approach from the northeast over the Florida Straits on runway 09/27. A left-side seat on approach gives a clear view of the full length of Key West island, the historic Old Town district, and the surrounding turquoise shallow waters of the Gulf of Mexico and Atlantic. Notable sights include: Key West Old Town and Duval Street grid, Stock Island, the chain of Lower Florida Keys stretching northeast, turquoise shallow-water flats of the Gulf of Mexico.

The flight from Charlotte Douglas International (CLT) to Key West International (EYW) takes Approximately 2 hours to 2 hours 20 minutes.

The flight tracks south-southeast over the South Carolina Piedmont, then crosses into Georgia over the Savannah River watershed. The broad coastal plain of Georgia and northern Florida is visible, characterized by flat pine flatwoods and dark river systems like the Altamaha and Suwannee. Over central Florida, Lake Okeechobee — one of the largest lakes in the US — is often visible as a large dark oval. The route then crosses the southern tip of the Florida peninsula and the beginning of the Florida Keys chain, where the contrast between the dark green mangrove islands and the extraordinary pale turquoise of Florida Bay becomes the dominant visual feature on descent.