Sit on the Left side of the plane for the best views on flights from Charlotte to Minneapolis. Left side wins at both ends of the flight. During the cruise over Indiana and Illinois, the left side also faces slightly more toward the Great Lakes region and Chicago's distant glow if flying at dusk, while the right faces open farmland. Left is the clear choice for the full journey.

During takeoff from Charlotte Douglas International (CLT), sit on the Left side for the best views. Charlotte Douglas primarily departs northwest on runway 18C/36C or uses runways oriented roughly north-south. Climbing out northbound, the left (west) side gives you a clear look back at uptown Charlotte's skyline and the Catawba River corridor. The right side faces east toward suburban sprawl with fewer distinctive features. Notable sights include: Uptown Charlotte skyline, Catawba River/Lake Norman to the northwest, Lake Wylie to the southwest, I-85 corridor cutting northwest.

When landing at Minneapolis St Paul International (MSP), sit on the Left side for the best views. MSP typically lands from the east or southeast on runways 12L/12R or from the south on 17. On approach from the southeast, the left side faces north and west, giving you the best view of downtown Minneapolis, the Mississippi River gorge, and the Chain of Lakes. The right side faces south toward suburban sprawl. Notable sights include: Downtown Minneapolis skyline, Mississippi River gorge and bluffs, Chain of Lakes (Lake Calhoun/Bde Maka Ska, Lake Harriet), Fort Snelling at the river confluence.

The flight from Charlotte Douglas International (CLT) to Minneapolis St Paul International (MSP) takes Approximately 2 hours 45 minutes to 3 hours.

The route crosses the Blue Ridge foothills briefly after departure, then transitions to the flat agricultural plains of Kentucky and Indiana. Over central Indiana and Illinois, the landscape is a vast grid of corn and soybean fields with small towns and river systems including the Wabash and Illinois Rivers. Crossing into Wisconsin, the terrain becomes slightly more rolling with the Driftless Area visible to the west. The Mississippi River is crossed near La Crosse or the Twin Cities approach corridor.