Sit on the Left side of the plane for the best views on flights from Charlotte to St. Petersburg. The takeoff views are good on the right but relatively brief over flat Piedmont terrain. The left-side arrival into PIE over Tampa Bay with the Sunshine Skyway and downtown Tampa is the most visually distinctive moment of the whole flight, and left-side seats also get decent southbound views of the Florida coast on descent.

During takeoff from Charlotte Douglas International (CLT), sit on the Right side for the best views. CLT's primary departure runways (18C/36C and 18L/36L) mean southbound departures climb out heading roughly south-southwest toward PIE. A right-side seat gives you the Charlotte city skyline and uptown district as you bank, plus a clear view south over the Piedmont. Left side faces west toward less distinctive suburban sprawl. Notable sights include: Charlotte uptown skyline, Lake Norman to the northwest (visible from left but better framed on right bank), Lake Wylie to the southwest, Piedmont flatlands stretching south.

When landing at St Petersburg Clearwater International (PIE), sit on the Left side for the best views. PIE typically uses runway 17/35, with southbound arrivals on runway 17 approaching from the north. On final approach heading south, the left side faces east over Tampa Bay — a massive, visually dramatic body of water with the Sunshine Skyway Bridge and downtown Tampa visible. The right side looks west over the Gulf of Mexico, which is open water with less to see. Notable sights include: Tampa Bay, Sunshine Skyway Bridge, downtown Tampa skyline, St. Petersburg peninsula.

The flight from Charlotte Douglas International (CLT) to St Petersburg Clearwater International (PIE) takes Approximately 1 hour 20 minutes.

The flight tracks south-southwest over the South Carolina and Georgia Piedmont, crossing over or near Columbia SC, then into Georgia passing west of Savannah. The route crosses into Florida over the Big Bend region where the Gulf Coast curves, then descends over central Florida's lake-dotted interior — Lake City and Ocala areas — before the Tampa Bay approach. The Florida interior is notable for its dense scattering of small lakes visible from altitude.