Sit on the Right side of the plane for the best views on flights from Las Vegas to Indianapolis. The right side delivers the more dramatic takeoff experience with the Las Vegas Strip and Spring Mountains, and while the left side wins on landing, the overall scenic highlight of this route is the departure from Las Vegas. The right side also tracks the Colorado River corridor and southern Utah canyon country during cruise, offering better views of the Colorado Plateau terrain.

During takeoff from Mc Carran International (LAS), sit on the Right side for the best views. Departing Las Vegas, aircraft typically use runways 26L/26R heading west or 19L/19R heading south. On a northeast-bound flight to Indianapolis, the aircraft will bank left after departure, giving right-side passengers a sweeping view back over the Las Vegas Strip and the Spring Mountains to the west. Left-side passengers face the Frenchman Mountain and open desert. Notable sights include: Las Vegas Strip (hotels clearly visible), Spring Mountains and Charleston Peak to the west, Lake Mead to the east visible during the turn, Hoover Dam visible in the distance during climb.

When landing at Indianapolis International (IND), sit on the Left side for the best views. Indianapolis International typically uses runways 23L/23R for arrivals from the west, meaning the aircraft approaches from the northwest on a southeast heading. Left-side passengers get a clear view of downtown Indianapolis skyline and the White River as the aircraft descends over the western suburbs. Notable sights include: Downtown Indianapolis skyline with the Soldiers and Sailors Monument visible, White River snaking south of downtown, Eagle Creek Reservoir to the northwest on approach, Interstate 465 beltway loop visible around the city.

The flight from Mc Carran International (LAS) to Indianapolis International (IND) takes Approximately 3 hours 15 minutes.

The flight crosses the Colorado Plateau with the Grand Canyon visible to the south in early cruise, then tracks over the Four Corners region with Monument Valley and Canyonlands visible depending on exact routing. Over central Colorado the Rockies appear to the north. The flight then crosses the flat Kansas and Missouri plains before descending into Indiana. The Mississippi River crossing near St. Louis is a notable midpoint landmark, with the Gateway Arch potentially visible on clear days.