Sit on the Left side of the plane for the best views on flights from Phoenix to Buffalo. While takeoff offers desert scenery, the landing approach provides more dramatic and varied geography—Lake Erie, the Niagara River, and the escarpment create a more visually interesting descent than the relatively flat approach from the west.

During takeoff from Phoenix Sky Harbor International (PHX), sit on the Right side for the best views. Right-side seats offer views of the Salt River valley and the Phoenix metropolitan area spreading eastward. You'll see the urban grid and surrounding desert terrain as the aircraft climbs northeastward on typical departure routes. Notable sights include: Phoenix metropolitan area, Salt River valley, Superstition Mountains (distant southeast), Sonoran Desert.

When landing at Buffalo Niagara International (BUF), sit on the Left side for the best views. Left-side seats provide excellent views during the descent approach into Buffalo. You'll see Lake Erie's southern shoreline, the Niagara River, and the Niagara Escarpment as the aircraft descends from the west. Notable sights include: Lake Erie, Niagara River, Niagara Escarpment, Buffalo waterfront and downtown skyline.

The flight from Phoenix Sky Harbor International (PHX) to Buffalo Niagara International (BUF) takes Approximately 4 hours 15 minutes.

The flight path crosses the Appalachian plateau region. Notable features include the Ohio River valley (visible around the 2-hour mark), the ridge-and-valley topography of the Appalachian Mountains in Pennsylvania and New York, and Lake Ontario's southern shoreline visible during the final descent phase. The terrain transitions from high desert and basin-and-range topography in Arizona to increasingly green, forested, and water-rich terrain as the aircraft moves eastward into the Great Lakes region.